Fasoracetam is a new racetam nootropic that helps in relieving anxiety, enhances memory, and improves overall cognitive function. It reportedly enhances memory and cognition while relieving depression and anxiety. Recently, it has been approved as a treatment for ADHD symptoms.
Overview of Fasoracetam
Fasoracetam is a promising and exciting addition to the racetam family. It’s reported to have the ability to enhance memory and cognition while relieving depression and anxiety.
Additionally, it also has a potential for treating attention deficit hyperactivity disorder symptoms. Even though it is a new name on the nootropic scene, it was developed by a Japanese pharmaceutical company more than 20 years ago as a potential treatment for vascular dementia.
However, it was put on hiatus after a failed trial. The clinical data were then bought by NeuroFix in 2013. Clinical trials began in 2016 with its focus on treating ADHD symptoms in children. The experiments have shown a great promise as a potential ADHD treatment.
In 2016, the FDA accepted the substance for evaluation.
It is a research chemical of the racetam family. It is a putative nootropic that failed to show sufficient efficacy in clinical trials for vascular dementia. It is currently being studied for its potential use for attention deficit hyperactivity disorder. Wikipedia
Benefits and Effects of Fasoracetam
- Improves Memory Cognition
- Relieves Anxiety and Depression
- Potential ADHD Treatment
- Increases Creativity and Motivation
Improves Memory Cognition
It minimizes memory decline, forgetfulness, and amnesia. Individuals who use it report it positively impacts their memory. That is due to the chemical that it produces, which increases learning, memory and cognitive functions. [R]
Relieves Anxiety and Depression
Fasoracetam relieves anxiety, improves mood, and eases depression by acting on glutamate and gamma-aminobutyric acid (GABA). By up-regulating GABA and suppressing the excess production of the excitatory neurotransmitter glutamate, Fasoracetam offers a non-jittery and smooth feeling of calmness, relaxation and improved mood. [R] [R]
Potential ADHD Treatment
Attention deficit hyperactivity disorder (ADHD) is mainly found in young adults and children and affects 1:3 female and 1:2 male / female.
More than one third of the cases have symptoms that persist into adulthood and lead to significant disability2. Although genetic risk factors for ADHD are known, a significant gap exists in translating these insights to therapeutics that can be clinically useful.
The most effective treatment for ADHD is generally stimulants, which are not specific and can cause severe negative consequences.
A study on 30 individuals ranging between 12 to 17 years old test the impact of Fasoracetam on ADHD patients. The subjects were receiving fasoracetam for five weeks, after which improvements were observed relating to ADHD symptoms. [R]
Increases Creativity and Motivation
With more research done on Fasoracetam, the improvement in creativity and motivation progresses as well. Many users report that not only it makes them inspired by nature but keeps them motivated too. These self-reports are credible for boosting moods and ability to increase the release and production of the neurotransmitter acetylcholine which is responsible for cognition and learning.
How does Fasoracetam work in the brain?
In a study published in the journal Science Translational Biology and Medicine, the researchers found that fasoracetam is beneficial for enhancing cognition in animals by binding to the three metabotropic glutamate receptors.
Its a mixture between mGluR1 and mGluR6. It is associated primarily with positive allosteric modulation of receptors which leads to improved synaptic transmission and improved brain functions.
Positive allosteric modulation occurs when molecules bind to their receptors to make them more likely to bind with an agonist or other. In the context of agonistic reactions, a substance is activated on the receptor.
This binding between Fasoracetam and MgrRs leads to an increase in binding of agonists to MgrRs.
Fasoracetam does not have prescribed pharmacokinetics but according to clinical studies and anecdotal data the average daily intake is 10-20 mg. So a 20 mg dose is a good starting point.
Anecdotal reports suggest smaller doses of 15 to 30 mg per day, while dosages used in clinical trials for ADHD were 100, 200, and 400mg twice a day.
Personally I tried anywhere from 20 mg per dose to 60 mg per dose. The difference was barely notable to me.
Always pair it with Alpha GPC or any choline source to potentiate the effect and prevent a headache.
Fasoracetam Side Effects
What are side effects of Fasoracetam?
The safety and effectiveness of Fasoracetam in patients is determined by the clinical trials that have been performed.
Similarly, avoiding the possibility of a growing addiction may help reduce risk factors. Similar to other nootrops, many consumers can also feel temporary or severe effects such as: As a fasoracetom increases the choline level in brain cells, it is likely that the symptoms result from exhaustion of the brain choline levels.
It is fortunately possible to relieve the symptoms using choline supplements.
Taking chloroplatinol supplements can be harmful to your skin and can cause severe side reactions in your body.
It is safe when taken responsibly. The most common side effect, similar to all racetams, including fatigue, headache, and digestive discomfort.
Here is an ongoing discussion thread on Reddit’s stack advice regarding Fasoracetam usage that is packed with both information on the nootropic, as well as different user experiences (myself included), suggestions, and thoughts on the nootropic:
Some of the interesting & diverse comments from that thread:
Not from me, unfortunately. Made me feel worse. I’ve lost any faith in common nootropics because they do nothing for me. Oxetine
10-20mg gave me near instantaneous relief from anxiety—sublingual that is. tawatson2
While it seemed to help somewhat with anxiety (not a magic bullet) I also felt like some cognitive abilities were actually reduced by it. I had problems carrying out my work with usual performance and with internalizing new tasks. Sometimes you can’t judge if a nootropic really helps much of anything at all but in case of fasoracetam the downsides seemed pronounced enough for me not to continue.
Fasoracetam (as well as Coluracetam) is a new nootropic but has had numerous experiments done on it. However, it has already developed a strong force in the nootropic community.
Many people find it an excellent choice to relieve anxiety and depression. Some people also say that it helps in cognition, clarity, and focus. It works well when used responsibly.
An excerpt from Wikipedia’s page:
“Fasoracetam is a research chemical of the racetam family. It is a putative nootropic that failed to show sufficient efficacy in clinical trials for vascular dementia. It is currently being studied for its potential use for attention deficit hyperactivity disorder.
Fasoracetam appears to agonize all three groups of metabotropic glutamate receptors and has improved cognitive function in rodent studies. It is orally bioavailable and is excreted mostly unchanged via the urine.
Fasoracetam was discovered by scientists at the Japanese pharmaceutical company Nippon Shinyaku, which brought it through Phase 3 clinical trials for vascular dementia, and abandoned it due to lack of efficacy.
Scientists at Children’s Hospital of Philadelphia led by Hakon Hakonarson have studied fasoracetam’s potential use in attention deficit hyperactivity disorder. Hakonarson started a company called neuroFix Therapeutics to try to bring the drug to market for this use; neuroFix acquired Nippon Shinyaku’s clinical data as part of its efforts. neuroFix was acquired by Medgenics in 2015. Medgenics changed its name to Aevi Genomic Medicine in 2016. Clinical trials in adolescents with ADHD who also have mGluR mutations started in 2016.”
Frequently Asked Questions
What’s the effect of Fasoracetam?
I have been dosing for 3 days now. I started noticing my legs were becoming relaxed as if I took a benzo combined with that sense of horniness phenibut gave me when I first began taking it.
Typically after a few days of Phenibut use dopamine builds up which leads to euphoria combined with anxiolytic effects. Those effects have been long gone and
I’ve basically just been taking about 1.6 grams to avoid withdrawals.
I’ve gotten off it a few times only to go back on. Now i’m feeling the original effects coming back stronger after each dose of Fasoracetam.
I can honestly say I don’t feel many other effects aside from the Phenibut now. I’m dosing Phenibut low so its amazing that the effects are coming back with such low doses.
I’m wondering if Fasoracetam will completely abolish all Phenibut Withdrawal. It almost seems like that may be the case since its Re-upregulating Gaba B. I wish I understand the Upregulation and Downregulation process on a deeper level.