Fladrafinil (CRL-40-941)

Table of Contents

    Fladrafinil is a recently introduced wakefulness-promoting agent structurally similar to, as well as the prodrug, Modafinil. 

    According to Wikipedia, a prodrug is a “compound that, after intake, is converted within the body…..prodrugs are often designed to improve bioavailability…this reduces adverse or unintended effects.” This means, in simplified language, that our bodies convert Fladrafinil into Modafinil after ingestion. 

    It produces its effects by modulating the release of histamine, and increasing dopamine and norepinephrine levels in the brain. Research suggests it may be an effective treatment for narcolepsy and other sleep disorders.

    Fladrafinil also supports treating shift work/night shift sleep disorder and improves subjective ratings of cognitive functioning and sleepiness in healthy adults. These studies suggest fladrafinil is an effective treatment for various conditions, making it a promising new compound and a decent replacement for Modafinil and Adrafinil.


    Fladrafinil (also called CRL-40,941) is a eugeroic or “wakefulness-promoting agent” and a prodrug to Modafinil. It was initially developed by Laboratoire L. Lafon in the 1980s and used to treat narcolepsy and other sleep disorders.

    Fladrafinil has a similar structure to Adrafinil and Modafinil and is believed to work by increasing dopamine and norepinephrine levels in the brain. It is more potent than both Adrafinil and Modafinil, with a shorter half-life, which may be more effective for some people.

    It is not yet FDA approved for any use, however, is legal to both buy and possess without a prescription or any sort of paper requirement.

    Fladrafinil Benefits

    There are many potential benefits of fladrafinil. It is thought to act as a cognitive enhancer, and may improve memory, focus, and motivation. It may also help to improve mood and reduce anxiety.

    • Increases energy and productivity [1]
    • Boosts focus, attention, and concentration [2]
    • Improves subjective mental clarity [3]
    • Increases motivation and creativity [4]
    • Fast acting, non-addivtive, and safe [5]
    • Improves cognitive function in ADHD individuals [6]

    Increases energy and productivity

    Anecdotal reports suggest Fladrafinilincreases energy levels and productivity. This is because it inhibits the reuptake of dopamine, serotonin, and norepinephrine. As a result, more neurotransmitters are available in the brain, leading to enhanced mood and cognitive function. Since fladrafinil does not cause amphetamine-like stimulation, it is less likely to result in adverse side effects like anxiety and jitteriness.

    Boosts focus, attention, and concentration

    Fladrafinil improves focus, attention, and concentration by stimulating the brain and keeping it proactive. This benefits people who have trouble staying focused on tasks for prolonged periods. It is also known to improve subjective mental clarity and reducing fatigue-like symptoms.

    Improves subjective mental clarity

    Fladrafinil is structurally similar to Adrafinil and Modafinil, both of which work by increasing hypocretin levels in the brain. It has therefore been showing an improvement in mental clarity and is often used as a cognitive enhancer.

    Increases motivation and creativity

    Fladrafinil has been found to increase motivation and creativity. It does so by increasing levels of dopamine and norepinephrine in the brain, which leads to an increase in motivation and a flow-like state.

    Fast acting, non-addivtive, and safe

    Fladrafinil has a high bioavailability and therefore is fast-acting. This makes it popular for those about to embark on long, demanding tasks to kickstart and sustain their productivity, especially in longer working or studying sessions. Despite its fast-acting properties, fladrafinil is considered to be a safe and non-addictive drug.

    Improves cognitive function in ADHD individuals

    Fladrafinil is a suitable drug for both short and long-term use. It can effectively be used long-term for conditions such as ADHD, chronic fatigue syndrome, and in some cases, depression symptoms. It is known to improve cognitive function in people with ADHD. It is often used off-label as ADHD treatment.

    How Fladrafinil Works

    Fladrafinil is a prodrug of Modafinil, which means that it is not active but is converted into Modafinil in the body. It increases levels of histamine and glutamate in the brain. It is thought to work by blocking the action of histamine H1 receptors and glutamate NMDA receptors. This prevents the cells in the brain from becoming tired and promotes wakefulness.

    Fladrafinil has a similar mechanism of action to other wakefulness-promoting agents such as methylphenidate. However, it is less likely to cause side effects such as anxiety and agitation.

    Fladrafinil is thought to have a lower abuse potential than Modafinil and other wakefulness-promoting agents because it is not active and must be converted into Modafinil in the body before it can have any effect.

    Fladrafinil Dosage

    Fladrafinil is best taken orally with the minimum effective dose being 20mg. You can start there and increase up to 40mg as needed. Observe your reaction to the smaller dose and decide accordingly, but do not exceed 40mg in one dose.

    It is water-soluble and recommended to be taken without food as it may reduce its absorption.

    Fladrafinil Side Effects

    The side effects of Fladrafinil are unknown since there haven’t been enough clinical trials on it. However, as it is a synthetic derivative of Modafinil, it is likely to share the same side effects.

    These can, in rare cases, include headaches, nausea, diarrhea, and irritability.

    If you are considering taking Fladrafinil, speak with your medical professional to ensure it is safe for you, especially if you are already taking other medications or have medical conditions.


    Fladrafinil is a novel wakefulness-promoting agent that has recently hit the market. It’s designed to be an improved version of Modafinil, and effective in treating narcolepsy, shift work sleep disorder, and obstructive sleep apnea. Unlike stimulants such as caffeine or amphetamines, Fladrafinil does not appear to cause significant side effects or withdrawal symptoms.

    Additionally, it does not seem to interfere with normal daily activities like working or studying. While more research is underway on its long-term safety and efficacy, it appears to be a promising new treatment for a number of conditions.

    If you are struggling with excessive daytime sleepiness or insomnia, chronic fatigue, and constant low levels of energy, speak to your doctor about whether Fladrafinil may be the right nootropic for you.

    Frequently Asked Questions

    What is Fladrafinil?

    Fladrafinil is a wakefulness-promoting agent that was developed in the 1970s in France. It belongs to a class of drugs known as eugeroics, designed to increase alertness and energy. It is a prodrug to Modafinil. It is a popular nootropic among people who want to improve their focus and productivity.

    How does Fladrafinil work?

    Fladrafinil works by increasing the levels of two critical neurotransmitters in the brain: dopamine and norepinephrine. These neurotransmitters are responsible for promoting arousal, focus, and energy. By increasing their levels, Fladrafinil can help you stay alert and focused throughout the day.

    What are the benefits of Fladrafinil?

    Fladrafinil has several benefits that include increased focus and concentration, improved mental clarity, enhanced productivity, faster reaction time, and most importantly, reduced symptoms of fatigue.

    What are the side effects of Fladrafinil?

    The most common side effects of Fladrafinil, if any, may include a headache, dizziness, nausea, lethargy, and insomnia.

    Is Fladrafinil legal?

    Fladrafinil is not currently approved for use. However, it is legal to purchase and import for personal use. It is important to note that Fladrafinil is a research chemical and should only be used by people comfortable with experimenting with new substances.

    How do I take Fladrafinil?

    Fladrafinil should be taken orally with a glass of water. The recommended dose is 20-40mg, taken once or twice daily at the max. It is essential to start with a lower dose and increase gradually as needed. It can be taken with or without food.

    Where can I buy Fladrafinil?

    Nootropix offers 30, & 60ct of Fladrafinil 20mg capsules. Though its complicated to obtain Modafinil in Dubai, Fladrafinil is the closest available alternative. All products are lab-tested and verified for both product purity and identity.

    How long does Fladrafinil last?

    The effects of Fladrafinil typically last for 4-6 hours. However, some people may feel the effects for up to 12 hours. Experimenting with different doses to find what works best for you is essential.

    Is Fladrafinil safe?

    Fladrafinil has a relatively low risk of side effects when taken at the recommended dose. However, it is always essential to consult a medical professional before starting any new supplement.


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